Posted on March 7th, 2014 by Margaret Shepard
Joseph Murray, M.D., discusses a recent paper published in Pediatrics that looks at undiagnosed cases of celiac disease in children. This study examines if doctors were able to predict if a child had celiac disease based on the current detection guidelines.
The main objective of the study was to find out if doctors could predict the children that had undiagnosed celiac disease from using the current celiac disease detection guidelines. The study took place in Sweden and tested over 7,000 children for celiac disease. Children in the study were given a questionnaire to fill out before the screening asking questions about family history of celiac disease and symptoms commonly associated with celiac disease. The results showed that [...]
Posted on February 27th, 2014 by Margaret Shepard
Wondering what to do when a gluten free diet doesn't seem to be working? Sometimes a patient diagnosed with celiac disease goes a gluten free diet and the symptoms come back or the diet doesn't help at all. Joseph Murray, M. D., discusses different approaches doctors take to help patients with this problem.
The first approach is to review the original diagnosis of celiac disease. This involves looking back at the original biopsy and blood tests done before the patient went on gluten free diet. Sometimes a genetic test will be done to make sure the patient has the genetic type required for celiac disease. Sometimes the results will show the patient doesn't have celiac disease but have other [...]
Posted on February 19th, 2014 by Margaret Shepard
Joseph Murray, M.D., discusses a recent paper published from Isreal in the Health Economics Review that examines the economics of celiac disease. Not much is known about the economics and impact the diagnosis of celiac disease has on health care costs.
This study examines people diagnosed with celiac disease covered by one health insurance company and compares them to people that do not have celiac disease. The results show that people with celiac disease tend to have more health care costs and possibly more admissions to hospitals than the general public. The results also showed the costs of celiac disease are similar to patients that have diabetes or hypertension.
The major takeaways of this study are:
Posted on February 11th, 2014 by Margaret Shepard
This new test could help diagnosis celiac disease in patients who have already been on a gluten free diet and are concerned about going on a gluten challenge. In the past, patients would be challenged with gluten for six weeks or longer and some patients would experience symptoms that interfered with their daily lives. In this study, patients were given gluten for three days and had their blood tested for a blood cell reaction to gluten several days later. The researchers were able to distinguish between patients that had [...]
Posted on December 31st, 2013 by Brent Westra
Dr. Murray, who was a co-author of this study, also added that while the study showed a weak, but positive connection between having gliadin antibodies and autism, it did not reflect cause and effect. Rather, he suggests, it's possibly the consequence that a patient suspected of having autism is subjected to far more diagnostic testing than a patient without a suspected diagnosis of autism.
Dr. Murray is a Mayo Clinic gastroenterologist [...]
Posted on December 17th, 2013 by Brent Westra
Govindarajan Rajagopalan, Ph.D., Yogish C. Kudva, MBBS, and Joseph Murray, M.D., discuss research showing that the intestinal microbiome plays a large role in the development of type 1 diabetes and that gluten in the diet may modify the intestinal microbiome to result in increased incidences of type 1 diabetes.
In this study, non-obese diabetic mice (mice that grow to develop type 1 diabetes) had a dramatically reduced incidence of type 1 diabetes when fed a gluten-free diet. When the researchers added gluten back into the diets of mice, it reversed the protective effect the gluten free diet had provided.
There also was a measurable impact of the gluten on the bacterial flora of the mice, which might [...]
Posted on December 9th, 2013 by Brent Westra
Imad Absah, M.D., discusses a recent study published in Pediatrics that found an increased risk of celiac disease in children introduced to gluten after 6 months, as well as in children breastfed after 12 months age.
The link between the timing of gluten introduction into an infant's diet and the risk of developing celiac disease have been studied before, and using those studies along with this most current study, Dr. Absah discusses that:
Posted on November 24th, 2013 by Brent Westra
Joseph Murray, M.D., discusses a recent article published in BMC Neurology that found patients who had sustained head trauma were at a slightly increased risk for celiac disease in the year following their injury.
The authors of the study hypothesized that perhaps: