Celiac Disease

Discussing the latest advances in celiac disease

Items Tagged ‘celiac disease’

January 30th, 2017

Does Celiac Disease Contribute to Other Autoimmune Diseases?

By Kanaaz kanaazpe

Dr. Joseph Murray, M.D., addresses a question posted by a member on Mayo Clinic Connect: Are there any proven links between mesenteric panniculitis and other autoimmune diseases I have, such as celiac disease or small fiber neuropathy?

Mesenteric Panniculitis is a rare inflammatory disease that affects the subcutaneous adipose tissue of the mesentery or the small bowel area that is characterized by blockage to the small intestine; it can be associated with other immune disorders, like celiac disease. However, celiac disease does not contribute to mesenteric panniculitis,  but rather that the inflammation in the intestine could affect inflammation in the mesentery, as they are so closely related.

With regard to neuropathy, celiac disease could be one of the leading factors for peripheral neuropathy, but its association with other neurological disorders is not clear, and requires more research.

For more information about celiac disease, please visit mayoclinic.org/celiac disease

For more information about Mayo Clinic Connect, please visit connect.mayoclinic.org

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: celiac disease, Joseph Murray, Mayo Clinic Connect, mesenteric panniculitis, peripheral neuropathy, small fiber neuropathy


December 20th, 2016

Tips for a Healthy Holiday Season

By Kanaaz kanaazpe

Jacalyn See and Madalynn Strong, registered dietitians from Mayo Clinic’s Celiac Clinic discuss valuable tips for maintaining a gluten-free diet during the holidays.

For more information about celiac disease, visit mayoclinic.org/celiac disease

 

 

 

 

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Tags: celiac disease, diet, dietitian, Gluten Free, holidays, Jacalyn See, Madalynn Strong


December 15th, 2016

When Your Diagnoses of Celiac Disease is in Question

By Kanaaz kanaazpe

Blood tests for celiac disease are usually accurate, but what does it mean when there is a discrepancy between biopsies suggesting celiac disease, but blood tests are negative?

In response to a question from a Mayo Clinic Connect member, Dr. Joseph Murray, M.D., explains that there may be other conditions that can cause changes in the intestinal biopsy that are characteristic of celiac disease. Tropical sprue, certain medications, or infections can cause damage to the intestinal wall.

Other reasons could be IgA deficiency; people with this disorder have absent levels of a blood protein called immunoglobulin A (IgA), which protects against infections of the mucous membranes lining the mouth, airways and digestive tract.

Why is it important to investigate and identify intestinal damage when test discrepancies occur? They may have alternate causes and subsequently alternate treatment, Dr. Murray emphasizes.

For more information about celiac disease, visit mayoclinic.org/celiac disease

Dr. Murray, M.D., is a gastroenterologist and celiac disease expert at Mayo Clinic.

 

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Tags: celiac disease, https://connectmayoclinicorg, IgA, intestinal damage, Joseph Murray, tropical sprue


May 11th, 2016

The Oats Conundrum

By Kanaaz kanaazpe

A plethora of questions surrounds patients with celiac disease, regarding the consumption of oats while following a gluten-free diet. Dr. Joseph Murray, M.D., and Jacalyn See, clinical dietitian, take an in-depth look and discuss some of the misconceptions about oats and the celiac patient.

Points to consider:

In response to numerous queries concerning the use of oats in various products, the North American Society for the Study of Celiac Disease (NASSCD) has developed this statement: "Based on the available scientific evidence, the use of oats uncontaminated by wheat, barley or rye by individuals with celiac disease and dermatitis herpetiformis in North America has been endorsed by most experts. Oats can add diversity and offer many nutritional benefits to the gluten-free diet."

Oats do not naturally contain gluten. The main problem with oats in gluten-free eating is contamination during harvest and storage. Many commercial oats are processed in facilities that also process wheat, barley, and rye. The gluten in these ingredients can contaminate oats, and with most gluten intolerances, even a trace amount of gluten can cause severe discomfort. Therefore,  it has been stressed that the oats be certified as pure.

Oats contain a protein called "avenin" that has the same properties as gluten. However, adverse reactions to this oat protein are very rare. More commonly, some patients may react to the fiber content or the fermentable carbohydrates in oats, both of which can cause gas, bloating and diarrhea.

There have been extensive studies done in adults and children, and clinical reports now provide strong evidence that pure oats very rarely cause damage to the gut mucosa in people with celiac disease.

Jacalyn See urges patients to check with their doctor and dietitian before introducing oats, and to start very slowly. It is important to ensure the oats are labelled gluten-free, but if there is suspicion of contamination, See advises patients to contact the FDA's MedWatch; save all packaging so that the source of contamination can be traced.

Oats are a great source of nutrients that are often lacking in the gluten-free diet, such as iron and fiber. Dr. Murray concludes that, "There is renewed hope and new opportunity for celiac disease patients to expand their diet to an area of the past where they felt uncomfortable doing so before."

Read more about the oats statement by NASSCD, here

For more information about celiac disease, visit mayoclinic.org/celiac disease

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

Jacalyn See is a registered clinical dietitian at Mayo Clinic

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Tags: celiac disease, FDA, Gluten Free Diet, Jacalyn See, Joseph Murray, MedWatch, oats


May 10th, 2016

Ultra-short Celiac Disease

By Kanaaz kanaazpe

Celiac disease primarily affects the small intestine, which is about 25 feet long. When celiac disease affects the duodenal bulb, the topmost part of the duodenum, it is diagnosed as ultra-short celiac disease. A recent study, published in Gastroenterology, found that a single biopsy of the duodenal bulb significantly increases the diagnostic yield for celiac disease. Dr. Joseph Murray, M.D., explains the prevalence and clinical implications of ultra-short celiac disease.

Read the full study online here.

For more information about celiac disease, visit mayoclinic.org/celiac disease

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: celiac disease, duodenum, gastroenterology, Joseph Murray, ultra-short celiac disease


May 10th, 2016

New Drug Shows Promise for Celiac Patients

By Kanaaz kanaazpe

So far, treatment for celiac disease has been limited to a gluten-free diet, but as clinicians and researchers understand more about the causes of this disease, it has opened up many avenues for development of new treatment. There are at least 3 drugs that have shown hints of promise in small clinical trials, and larazotide acetate is the first one that will soon advance to the final stage of testing. Researchers observed that the compound reduces the permeability of the gut, and found that the combination of the drug with a gluten-free diet reduces the symptoms of celiac disease better than a gluten-free diet on its own. Dr. Joseph Murray, M.D., provides some insight into this exciting development that may hold the key to a better future for patients living with celiac disease.

Read more about the study here.

For more information about celiac disease, visit mayoclinic.org/celiac disease

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: celiac disease, Joseph Murray, Larazotide Acetate, Phase-3 clinical trial


May 6th, 2016

Liver Involvement in Celiac Disease

By Kanaaz kanaazpe

Although celiac disease primarily affects the gut, the clinical spectrum of celiac disease is remarkably varied, and the disease can affect many extraintestinal organs, including the liver. Dr. Joseph Murray, M.D., reviews a study published in the World Journal of Gastroenterology, which identifies strategies for the diagnosis and treatment of these disorders in childhood.

Celiac disease is increasingly reported in children who are symptomless or present atypical symptoms and signs. As the medical community learns more about the far reaches of celiac disease, its association with liver ailments is receiving greater attention. Liver abnormalities can range from mild hepatic injury to severe liver disease. Although rarely, celiac disease may be also associated with severe liver involvement requiring liver transplant. All of these findings confirm the importance of early diagnosis and treatment of celiac disease-associated liver diseases.

Read the full study online here.

For more information about celiac disease, visit mayoclinic.org/celiac disease.

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: celiac disease, Joseph Murray, liver disease, Pediatric, World Journal of Gastroenterology


May 5th, 2016

The Gluten-Free Diet: A Practical Look

By Kanaaz kanaazpe

Celiac disease is a global disease, and currently the only available treatment is a gluten-free diet. In the developed world there are a lot of resources for people with celiac disease who need to be on a gluten-free diet, but it is still a substantial challenge. As celiac disease is being diagnosed in other countries, social, financial, cultural differences come into play, and can impact the ability of the celiac patient to follow a gluten-free diet. Dr. Joseph Murray, M. D., co-author of a recent paper published in Nature Reviews, Gastroenetrology and Hepatology, reviews some of these challenges and suggests strategies to maximize successful treatment, achieve healing, and prevent complications.

Some important highlights from the article:

  • The goals of treatment are best achieved when patients are managed by a team approach, including expert physicians and dietitians and community support.
  • The grains to be avoided on a gluten-free diet are wheat, barley and rye.
  • Patients with celiac disease must become expert label readers, and, because product ingredients change, must re-check labels at each purchase.
  • Worldwide, the availability of gluten-free foods is limited, especially in less-developed areas. Patients with celiac disease might access standard gluten-free foods by prescription and, in developed countries, many supermarkets now provide gluten-free sections.
  • The requirement for a strict gluten-free diet often affects social interactions. The burgeoning interest in gluten-free foods has led restaurants to offer gluten-free options on their menus. Many travel websites and mobile apps identify gluten-friendly restaurants, hotels, cruises and grocers near one's travel destination.
  • Once the diagnosis of celiac disease has been made, patients should be taught about the gluten-free diet with appropriate follow-up according to the individual's needs until a good understanding is achieved.
  • Dietary adherence is essential to achieve small bowel mucosal healing and alleviation of gastrointestinal symptoms.

Dr. Murray concludes that, "Central to success is engagement of the public health system, of doctors and dietitians who can support celiac patients in achieving wellness through a gluten-free diet."

Read the full journal review online here.

For more information about celiac disease, visit mayoclinic.org/celiac disease.

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: celiac disease, Gluten Free Diet, Joseph Murray, mucosal healing, Nature Reviews


April 19th, 2016

The Gluten ELISA Test Kit

By Kanaaz kanaazpe

If you have celiac disease, you may rely on commercial test kits for detecting gluten in food. But how reliable are these test kits for gluten detection? Dr. Joseph Murray, M.D., evaluates the ELISA test kits, based upon a study published in Cereal Chemistry.

The team of researchers who set out to evaluate the accuracy of 14 ELISA kits for gluten detection found that none of the currently available ELISA methods can accurately detect and quantify gluten in all cases. In the face of these results, Dr. Murray has the following recommendations for individuals who use the kits:

  • The FDA allows food products containing less than 20 parts per million of gluten to be labeled as gluten-free.
  • Be very cautious, and repeat the test multiple times.
  • Pay attention to the quality of the test.
  • Make sure that the test is appropriate for the matrix of the food type.

The authors of this study conclude that further improvements are urgently needed, and recommend focusing on competitive formats, improving extraction methods, and the detection of relevant gluten peptides.

Read the full study online here.

For more information about celiac disease, visit mayoclinic.org/celiac disease.

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

 

 

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Tags: celiac disease, Cereal Chemistry, ELISA test, FDA, gluten, Gluten Free, Joseph Murray


April 11th, 2016

Following Opportunity: Dr. Joseph Murray, Recipient of the NUI Galway 2016 Alumni Award

By Kanaaz kanaazpe

NUI Galway, in Ireland, ranked among the top 2% of universities in the world recently presented the Alumni Awards, recognizing individual excellence and achievements among the University’s more than 80,000 graduates worldwide. Amongst an impressive roll call of outstanding graduates who have gone on to honour their alma mater, Dr, Joseph Murray, M.D. received the 2016 Alumni Award for Medicine, Health Science and Nursing. Here is a brief look into Dr. Murray's passion for his work on celiac disease:

https://www.youtube.com/watch?v=gRb6siXcH7k&app=desktop

For more information about celiac disease, visit mayoclinic.org/celiac disease.

Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.

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Tags: awards, celiac disease, Joseph Murray, NUI Galway


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