- In patients with celiac disease, neurological disorders that develop are diverse in their presentation and may be caused by nutritional deficiency due directly to celiac or a coexisting autoimmune disorder of the nervous system, or by other things (some of which may be unrelated to celiac disease). In some patients gluten free diet helps. For some of those patients diet heals the gut, which stops the nutritional deficiency, which in turn stops the neurological problem. In a minority of other patients gluten free diet helps but the mechanism by which this happens is not known. It has been hypothesized that gluten directly triggers CNS inflammation, but this is unproven. The Tg6 antibody is not a sensitive or specific marker of this.
- Positivity for old-fashioned gliadin antibodies in patients without celiac disease are of dubious gastrointestinal and neurological significance.
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For more information on celiac disease, visit mayoclinic.org/celiacdisease.